HNA-3a-specific antibodies recognize choline transporter-like protein-2 peptides containing arginine, but not glutamine at Position 154
نویسندگان
چکیده
منابع مشابه
Many de novo donor‐specific antibodies recognize β2‐microglobulin‐free, but not intact HLA heterodimers
Solid-phase single antigen bead (SAB) assays are standard of care for detection and identification of donor-specific antibody (DSA) in patients who receive solid organ transplantation (SOT). While several studies have documented the reproducibility and sensitivity of SAB testing for DSA, there are little data available concerning its specificity. This study describes the identification of antib...
متن کاملIdentification of the HNA-3a antigen.
Among the 5 HNA systems, HNA-3 was the only one that had yet to be characterized. This effort was critical because antibodies directed to HNA-3a are responsible for causing numerous cases of transfusion-related acute lung injury (TRALI), especially fatal TRALI.2-4 Antibodies to HNA-3a cause neutrophil (PMN) agglutination, priming of the PMN oxidase, and PMN-mediated killing of pulmonary endothe...
متن کاملAnti-HmuY Antibodies Specifically Recognize Porphyromonas gingivalis HmuY Protein but Not Homologous Proteins in Other Periodontopathogens
Given the emerging evidence of an association between periodontal infections and systemic conditions, the search for specific methods to detect the presence of P. gingivalis, a principal etiologic agent in chronic periodontitis, is of high importance. The aim of this study was to characterize antibodies raised against purified P. gingivalis HmuY protein and selected epitopes of the HmuY molecul...
متن کاملGlutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats.
BACKGROUND & AIMS Increased intestinal permeability occurs during chemotherapy-induced intestinal mucositis. Previous data suggest that glutamine and arginine may have additive or synergic effects to limit intestinal damage. The present study aimed to evaluate the effects of glutamine and arginine, each alone or in combination, on gut barrier function during methotrexate (MTX)-induced mucositis...
متن کاملReality Does Not Recognize Borders
Reality does not recognize borders. Why we should use the very general term of “reality” and not science, because the borders that we draw are pure delusions, and on the opposite side there is the reality. The laws of the universe, either the physical nature of the world which the scientist studies or metaphysics which is the territory of philosophers, it isthe same reality that rules. Today ma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transfusion
سال: 2011
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2011.03145.x